Also known as: NR, Niagen, TRU NIAGEN
Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to NAD+, a coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activation. It is studied for its potential to support brain health, metabolic function, and healthy aging.
Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 that serves as the most efficient oral precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ levels decline significantly with age, and this decline is implicated in mitochondrial dysfunction, impaired DNA repair, neurodegeneration, and metabolic disease. NR is converted to NAD+ via the enzyme nicotinamide riboside kinase (NRK), bypassing the rate-limiting step of the salvage pathway used by standard niacin and nicotinamide. Clinical trials have demonstrated that NR supplementation effectively and dose-dependently raises NAD+ levels in blood and tissues. Elevated NAD+ activates sirtuins (SIRT1–SIRT7), a family of longevity-associated enzymes involved in DNA repair, epigenetic regulation, and mitochondrial function. NR is commercially available as Niagen (patented by ChromaDex) and has GRAS (Generally Recognized As Safe) status from the FDA.
Multiple clinical trials demonstrate that NR supplementation at 250–1.000 mg/day significantly and dose-dependently increases NAD+ concentrations in whole blood by 40–90% within 2–4 weeks.
By replenishing NAD+ stores and activating sirtuins, NR supports mitochondrial function, fatty acid oxidation, and insulin sensitivity. Clinical studies show improvements in markers of metabolic health.
Preclinical studies show NR protects against neurodegeneration by maintaining axonal NAD+ levels and activating SIRT3, which protects neurons from excitotoxicity and oxidative damage.
Single dose in the morning, with or without food
Doses up to 1.000 mg/day have been used safely in clinical trials. Start at 250 mg and increase as desired. Effects on NAD+ levels are measurable within 2 weeks.
Divided into 2 doses, morning and midday
Higher doses may be beneficial for older adults or those with significantly depleted NAD+ levels. No significant adverse effects observed at these doses.
Clinically validated dosing
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