Also known as: trans-Resveratrol, 3,5,4'-Trihydroxystilbene
Resveratrol is a polyphenolic stilbene found in grape skins, red wine, and Japanese knotweed. It activates sirtuins and AMPK pathways, and is studied for its antioxidant, anti-inflammatory, and cardioprotective properties.
Resveratrol (trans-3,5,4'-trihydroxystilbene) is a naturally occurring polyphenol produced by plants in response to stress and pathogen attack. It has gained significant scientific attention due to its activation of SIRT1 and other sirtuins—NAD+-dependent deacetylases involved in cellular stress resistance, metabolism, and aging. Resveratrol also activates AMPK, inhibits NF-κB-mediated inflammation, and improves endothelial nitric oxide synthase activity, contributing to vascular health. Clinical trials have demonstrated improvements in flow-mediated dilation, reductions in inflammatory markers such as CRP and TNF-α, and modest improvements in glycemic control in type 2 diabetes patients. Its bioavailability is limited by rapid glucuronidation and sulfation, leading to the development of micronized and liposomal formulations. Resveratrol is available as capsules, tablets, and liquid formulations, typically derived from Japanese knotweed (Polygonum cuspidatum) or grape extracts.
Resveratrol improves endothelial function and flow-mediated dilation, reduces oxidized LDL, and lowers systemic inflammation markers in multiple randomized controlled trials.
Resveratrol activates SIRT1 and AMPK, pathways involved in cellular stress resistance, mitochondrial biogenesis, and metabolic regulation, mimicking aspects of caloric restriction.
Meta-analyses demonstrate that resveratrol supplementation significantly reduces C-reactive protein, TNF-α, and other inflammatory biomarkers in clinical populations.
Once or twice daily with meals
Choose trans-resveratrol formulations for maximum bioactivity. Micronized or liposomal forms may improve absorption.
Once daily with food
Lower doses may be sufficient for general health maintenance.
Enhanced absorption and consistent dosing
Maximum bioavailability
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