Also known as: Senna alexandrina, Cassia angustifolia, Tinnevelly Senna
Senna is a stimulant laxative herb containing anthraquinone glycosides (sennosides) that act on the large intestine to promote bowel movements. It is clinically validated for short-term treatment of occasional constipation.
Senna (Senna alexandrina, syn. Cassia angustifolia) is one of the most widely used herbal laxatives globally and is included in the WHO Essential Medicines List. Its active compounds, sennosides A and B, are prodrugs that are metabolized by colonic bacteria to rhein anthrone, which stimulates peristalsis by acting on enteric neurons and increasing fluid secretion into the colonic lumen. Clinical trials confirm senna's efficacy for short-term relief of constipation, with onset of action typically within 6–12 hours. It is frequently used for bowel preparation before colonoscopy in combination with polyethylene glycol. Senna is not intended for long-term use due to potential electrolyte imbalances, particularly hypokalemia, and the development of melanosis coli with chronic use. It is available as tablets, capsules, teas, and liquid extracts, with dosing standardized to sennoside content.
Multiple randomized controlled trials and systematic reviews confirm senna as an effective short-term treatment for constipation, with onset of action within 6–12 hours.
Senna combined with polyethylene glycol is an established regimen for colonoscopy bowel preparation, shown to improve colon cleansing quality in clinical trials.
Once daily at bedtime
Start with the lowest effective dose. Not recommended for use beyond 1–2 weeks without medical supervision. Drink adequate fluids.
Precise dosing and reliable onset
Mild laxative effect and preference for traditional preparation
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