Also known as: Pantothenic Acid, Pantothenate, Dexpanthenol (topical)
Vitamin B5 (pantothenic acid) is a water-soluble vitamin essential for the synthesis of coenzyme A (CoA), a molecule central to fatty acid metabolism, energy production, and the synthesis of hormones and neurotransmitters.
Pantothenic acid, vitamin B5, derives its name from the Greek word 'pantos' meaning 'everywhere', reflecting its widespread presence in foods. It is a component of coenzyme A (CoA), which is involved in over 100 metabolic pathways including the synthesis and oxidation of fatty acids, the citric acid cycle (via acetyl-CoA), and the production of steroid hormones, melatonin, and acetylcholine. Pantothenic acid is also a constituent of acyl carrier protein (ACP), which is essential for fatty acid synthesis. Clinical deficiency is extremely rare due to the vitamin's ubiquity in the food supply. In its topical derivative form, dexpanthenol, it is widely used in wound healing and skincare products. No tolerable upper intake level has been established due to a lack of reported toxicity.
Pantothenic acid is required for the synthesis of CoA, which is essential for the citric acid cycle, fatty acid oxidation, and the biosynthesis of cholesterol, steroid hormones, and haemoglobin.
Topical dexpanthenol accelerates re-epithelialisation and improves skin barrier function, making it effective for minor wounds, burns, and dermatitis.
With a meal
Adequate intake (AI) is 5 mg/day for adults. Most people meet this through diet alone. No upper limit established.
General supplementation (commonly found in B-complex formulas)
Topical skin repair and wound healing
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