Nootropics

Lion's Mane is an edible medicinal mushroom that stimulates nerve growth factor (NGF) synthesis. It is widely studied for its neuroprotective, cognitive-enhancing, and mood-supporting properties.

CDP-Choline (citicoline) is an endogenous nucleotide that provides both choline and cytidine for brain phospholipid synthesis. It is one of the most well-researched nootropic compounds with strong evidence for neuroprotection.

Alpha-GPC is the most bioavailable choline supplement, efficiently crossing the blood-brain barrier to support acetylcholine synthesis. It is used for cognitive enhancement and as an adjunct in dementia treatment.

Phosphatidylserine is a phospholipid essential for neuronal cell membrane integrity and signaling. It is one of the few supplements with an FDA-qualified health claim for reducing cognitive decline risk.

Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to NAD+, a coenzyme essential for cellular energy metabolism, DNA repair, and sirtuin activation. It is studied for its potential to support brain health, metabolic function, and healthy aging.

Piracetam is the original nootropic, a cyclic derivative of GABA developed in the 1960s. It is widely studied for its effects on cognitive function, memory, and cerebral blood flow.

Huperzine A is a naturally occurring alkaloid from Chinese club moss that potently inhibits acetylcholinesterase, increasing acetylcholine levels in the brain. It is studied as both a nootropic and adjunct Alzheimer's therapy.

PQQ is a redox-active cofactor that stimulates mitochondrial biogenesis and protects neurons from oxidative damage. It is studied for its potential to enhance cognitive function, energy metabolism, and cellular longevity.

Modafinil is a prescription wakefulness-promoting agent used to treat narcolepsy, shift work disorder, and obstructive sleep apnea. It is widely studied off-label for its cognitive-enhancing effects on attention, executive function, and memory.

Vinpocetine is a semi-synthetic alkaloid derived from the periwinkle plant that enhances cerebral blood flow and has neuroprotective properties. It is widely used in Europe for cerebrovascular disorders.

Phenylpiracetam is a phenylated derivative of piracetam with significantly greater potency and stimulant-like properties. It enhances cognition, physical performance, and cold tolerance, and is banned by WADA as a performance-enhancing substance.

Uridine is a pyrimidine nucleoside that plays a key role in brain phospholipid synthesis, synaptic plasticity, and dopamine modulation. It is studied for its potential to enhance memory, mood, and neuronal membrane integrity.

Sulbutiamine is a synthetic lipophilic derivative of thiamine (vitamin B1) that readily crosses the blood-brain barrier. It is used to combat fatigue, enhance memory, and support dopaminergic and cholinergic neurotransmission.

Noopept is a synthetic peptide-derived nootropic developed in Russia that is estimated to be up to 1.000 times more potent than piracetam on a per-milligram basis. It modulates AMPA and NMDA receptors and increases BDNF and NGF expression.

Aniracetam is a fat-soluble racetam nootropic that modulates AMPA receptors and is studied for its anxiolytic and cognition-enhancing properties. It is more potent than piracetam on a per-milligram basis.